The Brown Foundation Institute for Molecular Medicine (IMM) is the hub of a new alliance connecting research efforts across the university in systems biology, clinical and translational sciences, protein chemistry, genomics, and proteomics. This new multidisciplinary science will link the efforts of various centers, bringing together people to promote intellectual exchange and the transfer of expertise in these key fields and beyond.
The Centers for Proteomics and Systems Biology will create a critical mass of investigators with diverse expertise but a common interest that will benefit the entire research community by providing technological, informatics and educational resources.
Leadership
Hongyu Wang, M.D., Ph.D. | Core Director
Li Li, M.S. | Sr. Mass Spectrometrist, Core Manager
The Image Oriented Navigation Laser Microdissection Device (ION LMD) offers a unique feature of UV laser microdissection to efficiently isolate single or group of cells from tissue sections without changing morphology or integrity of the biological content. Using LMD technology, quality material for a wide variety of DNA, RNA, and protein analyses can be obtained for sensitive and accurate molecular assays such as Sanger sequencing, next-generation sequencing, quantitative PCR, and proteomics mass spectrometry analysis. Beyond the optical microscope function, our fluorescence light source enables us to microdissect any fluorescence labeled cells or tissue.
Our proteomics core laboratory offers services to train users to use LMD microscope and help to perform LMD based on request.
The window slide is made of anti-static engineering plastic of PEI material and PEN film with a thickness of 1.5 microns. It has the same function as that of conventional glass slide but holds a super thin film to support the tissue section.
The Image Oriented Navigation Laser Microdissection Device (ION LMD) offers a unique feature of UV laser microdissection to efficiently isolate single or group of cells from tissue sections without changing morphology or integrity of the biological content. Using LMD technology, quality material for a wide variety of DNA, RNA, and protein analyses can be obtained for sensitive and accurate molecular assays such as Sanger sequencing, next-generation sequencing, quantitative PCR, and proteomics mass spectrometry analysis. Beyond the optical microscope function, our fluorescence light source enables us to microdissect any fluorescence labeled cells or tissue.
Our proteomics core laboratory offers services to train users to use LMD microscope and help to perform LMD based on request.
The window slide is made of anti-static engineering plastic of PEI material and PEN film with a thickness of 1.5 microns. It has the same function as that of conventional glass slide but holds a super thin film to support the tissue section.
The Flow Cytometry and Cellular Imaging Facility was established to provide access to state of the art cell analysis technology for researchers, and provides cell sorting, analytical flow cytometry, cellular imaging and custom monoclonal antibody mAb conjugations to its users.
The mission of the Proteomics and Metabolomics Core Facility is to provide the research community with cutting edge expertise and services for sensitive, precise, and accurate measurement of proteins and metabolites using mass spectrometrybased technologies.p</p>
Functional Proteomics Reverse Phase Protein Array RPPA Core provides cancer center members with access to a powerful, highthroughput, quantitative costeffective antibodybased assay to characterize basal or ligandinduced protein expression and modification, and timeresolved responses appropriat
The CTPC services provided are designed to identify and quantitate proteins and their modifications in a broad range of research specimens from simple purified protein samples to biomarker discovery and verification in complex mixtures such as cell and tissue extracts, plasma andor other biofluids
