Center for Advanced Microscopy

Overview of Services

The Center for Advanced Microscopy provides state of the art imaging capabilities as well as expertise to those within UT Health and the Texas Medical Center who have a need for cutting edge imaging technology. The instruments housed in the Center, as well as the expert individuals who stand ready to provide training, are available to provide access to vital imaging systems for the purpose of molecular, cellular, tissue, and whole animal imaging.

Leadership

Olga Chumakova, Ph.D. | Core Manager

Kandice Levental, Ph.D. | Core Director

Lisa Byrd | Sr. Administrative Coordinator

Location and hours of operation

Hours Location

Monday - Friday        

8am - 5pm 

6431 Fannin Street, Rm 4.532

Houston, Texas 77030

Services and Equipment Available for Reservation

To schedule time on a piece of equipment please proceed to the Schedule Equipment tab.

 

  • IVIS Lumina XR: live whole animal imaging of longitudinal fluorescence, bioluminescence, and X-ray in vivo and ex vivo
  • BD LSR Fortessa Cell Analyzer System: 5-laser flow cytometer that allows analysis of up to 13 different fluorochromes plus forward and side scatter
  • Nikon A1 Confocal Laser Microscope System + PicoQuant: confocal with additional platform for assessing fluorescence lifetime
  • Nikon A1R Confocal Laser Microscope System: confocal with resonant and spectral detectors
  • Flexstation-3: microplate reader for absorbance, fluorescence, fluorescence polarization, luminescence in high throughput mode
  • Zeiss 510 Meta Confocal Laser Scanning Microscope + ApoTome Structured Illumination: has a module for superresolution structured illumination
  • Nikon TiE Wide-Field Fluorescence Imaging System: for imaging of small molecules in living cells
  • Nikon two-camera Rig TE-2000U
  • Lambert LIFA Fluorescence Lifetime Imaging Microscope
  • Data Processing Computer: contains NIS-Elements AR, LI-FLIM, Living Image, MetaMorph, SlideBook, SoftMaxPro, AutoQuant 

Links and Resources

  1. IBP Cytodynamic Imaging Facility
  2. Department of Integrative Biology and Pharmacology
  3. Nikon Microscopy U
  4. Zeiss Website
  5. Aldehyde-based Fixatives
  6. Molecular Probes (Invitrogen) Fluorescent Spectra Viewer
  7. NIH Imagel Software
  8. Dirk Bucher's Confocal Guide
  9. Pierce (Thermo Fisher Scientific) Library of Technical Guides
  10. Quantifying Colocalization
  11. A Practical Guide to Evaluating Colocalization in Biological Microscopy
  12. ND Processing Tools
  13. Object Classifier 
  14. Binary Masks ROI
  15. Creating AVI Files
  16. Object Count
  17. Ratio Measurement
  18. Using Binary Layers
  19. Using References
  20. Using ROI

Contacts

Name Role Phone Email Location
Olga Chumakova, Ph.D.
Core Manager
 
713-500-7495
 
Olga.Chumakova@uth.tmc.edu
 
MSB 4.532
 
Kandice Levental, Ph.D.
Core Director
 
713-500-5566
 
Kandice.R.Levental@uth.tmc.edu
 
MSB 4.202A
 
Lisa Byrd
Sr. Administrative Coordinator
 
713-500-7508
 
Lisa.Byrd@uth.tmc.edu
 
MSB 4.206
 

Members at UT System

Core Name Primary Contact Email Phone Number/Ext
Biospecimen Extraction Facility

<p>The Biospecimen Extraction Resource BER provides a centralized laboratory for standardized, high quality DNA, RNA and protein extraction from blood, tissues, saliva, cells, or other patientderived biospecimens.</p>

Jian Gu, Ph.D. jiangu@mdanderson.org 713-792-8016
Characterized Cell Line Core Facility

The Characterized Cell Line distributes well characterized and validated cell lines to researchers across the world and offers cell line validation using short tandem repeats STR profiling.

Karina Eterovic CCSGCCLC@mdanderson.org
Core for Biomolecular Structure and Function (CBSF)

<p>The purpose of the Core for Biomolecular Structure and Function is to provide biochemistry and structural biology&nbsp;resources to the Texas Medical Center.</p>

Paul Leonard PLeonard1@mdanderson.org 832-750-1516
DNA Methylation Core

The DNA Methylation Core is funded by the Center for Cancer Epigenetics and provides services related to the analysis of DNA methylation for researchers at the University of Texas M.D. Anderson Cancer Center.

Marcos Estecio mestecio@mdanderson.org 713-792-9108
E-Health Technology

eHealth Technology supports technology enabled primary, secondary, and tertiary cancer prevention research through the development and implementation of multimedia intervention and data capture tools that address research questions

Core Email e-Health@mdanderson.org 713-794-4344
Gene Editing/Cellular Model Core Facility

The Gene Editing Cellular Model Core Facility provides custom cellular model construction services using two technical platforms.

Dr. Junjie Chen jchen8@mdanderson.org 713-792-4863
Genetically Engineered Mouse Facility (GEMF)

The Genetically Engineered Mouse Facility provides unique models with wide application to basic and translational research. The GEMF supplies indispensable expertise to generate these models in an efficient and costeffective manner using stateoftheart procedures.

Jan Parker-Thornburg, Ph.D. jpthorn@mdanderson.org 713-745-2654, 713-745-1419 (lab)
High Resolution Electron Microscopy Facility (HREMF)

The mission of the High Resolution Microscopy Facility is to provide scanning and transmission electron microscopy services to researchers.

Robert R. Langley, Ph.D. rlangley@mdanderson.org 713-792-9142, 713-792-8747 (fax)
Laboratory Animal Genetic Services

The Laboratory Animal Genetic Service Core provides services for speed congenics, background characterization, microbial PCR testing, rodent STR and murine genetic consultations.

Fernando Benavides, DVM, PhD, DACLAM fbenavid@mdanderson.org 512-237-9343
Molecular Cytogenetics Core Facility

The primary goal of this facility is to offer conventional and molecular cytogenetic services, including species identification, karyotyping, analysis of genomic instability, fluorescence in situ hybridization and spectral karyotyping

Asha S. Multani Ph.D. amultani@mdanderson.org 713-563-1892
Monoclonal Antibody Core Facility

The Monoclonal Antibody Facility develops high quality, cost effective customized MAbs to meet the basic, translational, and clinical research needs of MD Anderson investigators.

Laura Bover lbover@mdanderson.org 713-563-3301 or 713-563-2281
NORTH Campus Flow Cytometry and Cellular Imaging Core Facility

The Flow Cytometry and Cellular Imaging Facility was established to provide access to state of the art cell analysis technology for researchers, and provides cell sorting, analytical flow cytometry, cellular imaging and custom monoclonal antibody mAb conjugations to its users.

Joan Hoover-Zuniga jezuniga@mdanderson.org 713-745-1749
Nuclear Magnetic Resonance Facility

The NMR facility is used for structure determination of compounds developed in drug discovery, pharmacology, and diagnostic imaging laboratories.

John S. McMurray, Ph.D jmcmurra@mdanderson.org 713-745-3763
PROSPR

PROSPR provides assistance to researchers with collection and assessment of Patient Reported Outcomes, behavioral data, and measures of fitness and body composition.

Susan K. Peterson, PhD, MPH speterso@mdanderson.org 713-792-8267
Pharmaceutical Chemistry Facility

The mission of the Pharmaceutical Chemistry Facility is to assist researchers with the design and synthesis of compounds for use in cancer research.

Barbara Czako Ph.D BCzako@MDAnderson.org 713-745-2050
Protein Array & Analysis Core (PAAC)

The Protein Array and Analysis Core PAAC at the University of Texas MD Anderson Cancer Center Science Park provides investigators access to innovative and cutting edge cancer research tools for the discovery and characterization of novel proteinprotein interactions.

Cari Sagum casagum@mdanderson.org 512-237-9328
Proteomics and Metabolomics

<p>The mission of the Proteomics and Metabolomics Core Facility is to provide the research community with cutting edge expertise and services for sensitive, precise, and accurate measurement of proteins and metabolites using mass spectrometrybased technologies.p</p>

David Hawke, Ph.D dhawke@mdanderson.org 713-834-6096
RPPA-Functional Proteomics

Functional Proteomics Reverse Phase Protein Array RPPA Core provides cancer center members with access to a powerful, highthroughput, quantitative costeffective antibodybased assay to characterize basal or ligandinduced protein expression and modification, and timeresolved responses appropriat

Keri Sherman ccsgrppa@mdanderson.org 713-792-5743
Research Histology Core Laboratory

The Research Histology Core Laboratory includes specialized equipment for immunohistochemistry, fluorescent in situ hybridization FISH, laser capture microdissection, and tissue microarray construction.

Jacqueline Furr jfurr@mdanderson.org 713-792-3119, 713-563-0544 (fax)
Science Park Flow Cytometry and Cell Imaging Core

The Flow Cytometry and Cell Imaging Core Facility at Science Park provides cutting edge cell analysis resources. These include cell sorting and analytical flow cytometry to phenotype, quantify and isolate cells and confocal microscopy to capture high resolution images.p

Pamela Whitney - Lab pjwhitney@mdanderson.org 512-237-9427
Science Park Molecular Biology Core

The Molecular Biology Core Facility at Science Park provides investigators access to sophisticated and stateoftheart molecular techniques, services and instrumentation.

Jianjun Shen, Ph.D. jianshen@mdanderson.org
Science Park NGS

The Science Park NGS facility is built around a user group of 30 cancer researchers at MD Anderson Science Park, UT Austin, and Texas State University San Marcos.

Jianjun Shen, Ph.D jianshen@mdanderson.org
Science Park Research Histology, Pathology & Imaging Core

The Science Park Research Histology, Pathology Imaging Core provides investigators with expert imaging and experimental pathology support. Our staff consult with investigators to formulate an integrated imaging, pathology and histology protocol for each study.

Manu Sebastian, DVM, PhD, DACVP, DABT, DECLAM mmsebastian@mdanderson.org 512-237-9347
Sequencing and Microarray Facility (SMF)

The Sequencing and Microarray Facility provides essential genomic analysis services to support researchers in basic science, translational, and populationbased research programs

Erika Thompson, M.S. ejthomps@mdanderson.org 713-834-6381
Sequencing and ncRNA Program

The Sequencing and Noncoding RNA Program is one of an MDA institution supported shared genomic service resources providing not only instrumentation but also expertise in applications of next generation sequencing and microarray services to investigators

Chang-gong Liu, Ph.D. cgliu@mdanderson.org 713-792-2287
Small Animal Imaging Facility

The Small Animal Imaging Facility provides access to imaging instrumentation and expertise that allows researchers to integrate powerful and cuttingedge imaging technologies into routine preclinical research with confidence that their scientific objectives will be achieved.

Charles Kingsley charles.kingsley@mdanderson.org (713) 563-6709
shRNA and ORFeome Core

The shRNA and ORFeome core Facility makes the following libraries available to MD Anderson members human and murine shRNA libraries, human ORFeome collaboration and LentiORF libraries. The core not only provides center members with individual shRNA and ORF clones but also builds customized librar...

Dr. Sun, Yutong ysun2@mdanderson.org (713) 792-3677
siRNA Core Facility

The siRNA Core Facility at MD Anderson performs High Throughput and High Content siRNA screens to assist experimental cancer therapy studies. The cores ultimate goal is to develop relevant three dimensional models that represent the human body..

Core Name Primary Contact Email Phone Number/Ext
Kleberg Advanced Microscopy Center

KAMC focuses on the synthesis and characterization of nanomaterials for imaging, labels for bioassays, and active targeting for in vivo or in vitro diagnostics. The Core studies the interaction of nanoparticles with living cells for application in the targeted delivery of drugs, genes, and proteins.

Miguel Jose-Yacaman, Ph.D. miguel.yacaman@utsa.edu (210) 458-6954
Protein Biomarker Core

The RCMI Proteomics and Protein Biomarkers Core Facility is focused on capillary liquid chromatographymass spectrometry LCMS and tandem mass spectrometry LCMSMS to identify, characterize, and quantify proteins. The Proteomics Core develops novel methods, while the Protein Biomarkers Core applies ...

Stephan Bach, Ph.D. stephen.bach@utsa.edu (210) 458-4466
RCMI Biophotonics Core

The RCMI Biophotonics Core Facility provides cutting edge technology for the study and manipulation of biological samples using light, including longterm indepth imaging of live tissues and the technology to probe at the molecular level for proteinprotein interactions within live samples.

George Perry, Ph.D. george.perry@utsa.edu (210) 458-4450

University of Texas Health Northeast

Core Name Primary Contact Email Phone Number/Ext
Core Name Primary Contact Email Phone Number/Ext
Biomedical Informatics Group (BIG)

We offer services to researchers, including access to clinical data and enhanced subject recruiting, and are involved in multiple local and national collaborations with other groups.

Susan Guerrero Susan.C.Guerrero@uth.tmc.edu 713-500-3926
CCTS Biobank

The CCTS Biobank consists of a collection of human samples and related clinical and genomic data that are available for collaborative sharing with qualified researchers and owned by contributing investigators conducting research within the Texas Medical Center.

Mary Hall, MBA, PhD Mary.Hall@uth.tmc.edu 713.500.2092
Cellular Therapy Core

<p>The CTC is an FDA registered facility where tissues are processed to produce cells for clinical applications. It is focused on translating, validating and supporting IND applications at a preclinical level into clinical grade processes.</p>

Fabio Triolo, Ph.D. Fabio.Triolo@uth.tmc.edu 713-486-2542
Center for Advanced Microscopy

The Center for Advanced Microscopy provides assisted or unassisted state of the art imaging capabilities including three confocal microscopes, fluorescence lifetime imaging, live animal imaging with an IVIS Lumina, flow cytometry, and a liquid handling multiwell plate reader.

Olga Chumakova, Ph.D. Olga.Chumakova@uth.tmc.edu 713-500-7495
Flow Cytometry Service Center

The Flow Cytometry Service Center provides a broad range of assisted and unassisted flow cytometry services from basic 2 color analysis to advanced 14 parameter analysis and multi population cell sorting.

Amy Hazen, Ph.D. Amy.Hazen@uth.tmc.edu 713-500-2486
Human Genetics Center Laboratory

Magnetic Resonance Imaging Core

The MR group provides advanced MRI techniques, including selective tissue imaging, magnetic resonance spectroscopic imaging, diffusion tensor imaging to neurological disorders, central nervous system trauma, and drug addiction both in humans and animal models.

Ponnada Narayana, Ph.D Ponnada.A.Narayana@uth.tmc.edu 713-500-7677
Nano Chemistry Service Center

The Nanochemistry Service Center provides provides custom synthesis, labeling, and chemical coupling of DNA thioaptamers and nanoparticles and large-scale, high-resolution 3D printing services.

David Volk david.volk@uth.tmc.edu 713-500-3611
Proteomics Service Center

The CTPC services provided are designed to identify and quantitate proteins and their modifications in a broad range of research specimens from simple purified protein samples to biomarker discovery and verification in complex mixtures such as cell and tissue extracts, plasma andor other biofluids

Li Li Li.Li@uth.tmc.edu 713-500-2456
Quantitative Genomics & Microarray Service Center

The Quantitative Genomics Microarray Core Lab can perform all techniques associated with a qPCR instrument, quantitative Meso Scale ELISAs and microarrays utilizing Illumina and Agilent arrays.

David Loose, Ph.D. David.S.Loose@uth.tmc.edu 713-500-7440
Therapeutic Antibody Core

The Therapeutic Antibody Core aims to provide statewide support and service to advance lead antibodies from academic laboratories to the stage of preclinical development.

Zhiqiang An, PhD Zhiqiang.An@uth.tmc.edu 713-500-3011
Transgenic and Stem Cells Service Center

Eva Zsigmond eva.m.zsigmond@uth.tmc.edu 713-500-2453
Core Name Primary Contact Email Phone Number/Ext
Advanced Nucleic Acids Core Facility

Brian Wickes wickes@uthscsa.edu (210) 567-3938
Bioanalytics and Single-Cell Core

Nameer Kirma kirma@uthscsa.edu (210) 562-4068
Biobanking and Genome Analysis

Teresa L. Johnson-Pais, Ph.D. paist@uthscsa.edu 210.567.6571
Center for Macromolecular Interactions

Flow Cytometry Core Facility

Benjamin Daniel danielb@uthscsa.edu 210-567-3911
Mass Spectrometry Laboratory

Susan Weintraub, Ph.D. weintraub@uthscsa.edu (210) 567-4043
MicroCT Core Laboratory

James Schmitz schmitzj@uthscsa.edu 210-567-5155
NMR / Screening

Kristin E. Cano, Ph.D. canok@uthscsa.edu 210-567-8706
Optical Imaging Facility

Exing Wang wange3@uthscsa.edu 210-562-4062
X-Ray Crystallography

John Hart pjh@biochem.uthscsa.edu 210-567-0751

University of Texas Medical Branch - Galveston

Core Name Primary Contact Email Phone Number/Ext
International Biosafety Training Center

Sharon Walters skwalter@utmb.edu 409-772-1781
Research Histopathology Core

The Research Histopathology Core is equipped with the latest available instrumentation. RHC’s instrumentation is operated by highly skilled personnel available to assist in tissue preparation, immunohistochemistry, immunofluorescence, Insitu hybridization, including assay optimization, image anal...

Gustavo Valbuena gvalbuen@utmb.edu (409) 747-0735
Core Name Primary Contact Email Phone Number/Ext
Clinical Research Unit (CRU)/Investigational Drug Service (IDS) Lisa Fleming, MPA CRUAdministration@UTSouthwestern.edu 214.648.2718
Flow Cytometry Facility at UTSW David Farrar david.farrar@utsouthwestern.edu 24-648-7315
Genomics Sequencing & Microarray Core Facility Chaoying Liang Chaoying.Liang@UTSouthwestern.edu 214-648- 7329
High Throughput Screening Core Bruce Posner, Ph.D. bruce.posner@utsouthwestern.edu 214-648-0285
Metabolic Phenotyping Core Ruth Gordillo Ruth.Gordillo@UTSouthwestern.edu 214-648-3403
O'Brien Kidney Center: Animal Models Core Lauren Diana Smith LaurenD.Smith@UTSouthwestern.edu 214-648-7222
O'Brien Kidney Center: Cell Biology and Imaging Core Lauren Diana Smith LaurenD.Smith@UTSouthwestern.edu 214-648-7222
O'Brien Kidney Center: Clinical and Translational Research Core Lauren Diana Smith LaurenD.Smith@UTSouthwestern.edu 214-648-7222
O'Brien Kidney Center: Physiology Core Lauren Diana Smith LaurenD.Smith@UTSouthwestern.edu 214-648-7222
Preclinical Pharmacology Core Noelle Williams noelle.williams@utsouthwestern.edu 214-648-5072
Rodent Behavior Core Shari Birnbaum shari.birnbaum@utsouthwestern.edu 214-648-5123
Structural Biology Laboratory
Whole Brain Microscopy Facility (WBMF) Denise Ramirez, PhD denise.ramirez@utsouthwestern.edu 214-648-0203